https://www.ceesdekker.net Secrets
https://www.ceesdekker.net Secrets
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‘Yes, that is definitely about correct. I seek for a physical comprehension of Organic techniques inside of a bottom-up way. I believe you could possibly distinguish 3 strains of exploration in my team in the intervening time. The first worries chromosome composition: how do you obtain a metre-prolonged DNA polymer folded and organised in this kind of microscopic mobile? We've produced visualisation approaches that allow us to study how, by way of example, SMC proteins loop DNA (online video on Youtube) to be able to Construct up chromosomes.
Our team scientific tests bacterial cell division and it is aiming to represent a ‘base up biology’ in synthetic cells that can autonomously divide. Our most important fascination lies in cell division, chromatin structure, and spatial Command.
, Groningen researchers current the final results in their attempts to make labs far more sustainable and provide methods for other labs.
Our do the job was quickly followed up by Other people, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 released their conclusions on transistors comprised of one- and multi-walled carbon nanotubes in Used Physics Letters.
Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent style in 2005. (nl)
Our investigate ranges from the biophysics of DNA to synthetic cells and beyond. Please take a look down below ceesdekker.net within the spectrum of our present-day jobs.
We form germs into types that deviate from their all-natural phenotype. Particularly, I will clearly show our capacity to form Reside E. coli bacteria into novel styles for instance rectangles, squares, triangles and circles.
Atomic drive microscopy exhibits that vaccinia topoisomerase IB generates filaments on DNA in a very cooperative fashion
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one). The current–voltage curves confirmed substantial modulations with gate voltage, even at place temperature, which was in line with band bending inside of a ~0.6 eV bandgap semiconducting nanotube. These details also showed which the conductance could possibly be modulated by 6 orders of magnitude by modifying the gate voltage. The effects of this get the job done — a space-temperature transistor constructed from just one carbon nanotube molecule — ended up published in Character in May perhaps 1998.
Testing pseudotopological and nontopological types for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments
Character Physics thanks the nameless reviewers for his or her contribution towards the peer review of the perform.
Such as, we consider the nucleopore sophisticated, a gateway in between the cell nucleus as well as cytoplasm. This is an extremely difficult system and as a consequence challenging to examine inside a mobile, so we use biomimetics. We reconstruct holes and afterwards insert specific components of the nucleopore advanced to review transportation by it at the single-molecule amount.’
It absolutely was a really appealing time, throughout which I acquired loads of help from Delft College of Technology, in which I used to be a professor at some time, and I started out various collaborations with molecular biologists. That helped me find out quite a bit.’